Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload.

@article{Carroll1995GeneEI,
  title={Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload.},
  author={Susan M. Carroll and L E Nimmo and Paul S Knoepfler and Francis C. White and C. Bloor},
  journal={Journal of molecular and cellular cardiology},
  year={1995},
  volume={27 7},
  pages={1427-41}
}
We have investigated the molecular changes which occur during pressure overload hypertrophy of the RV in swine. Animals were banded on the pulmonary artery so that right ventricular pressure was increased two-fold. The heart was harvested at 3, 7, 24 and 72 h after surgery. Between 7 and 72 h there was evidence of muscle damage and inflammation. Northern… CONTINUE READING