Gene expression in a rarely studied intraabdominal adipose depot, the round ligament, in severely obese women: A pilot study.

Abstract

Gene expression (qPCR) was compared in round ligament (RL), omental (OME) and mesenteric (MES) ATs from 48 severely obese women (BMI, 54±11 kg/m(2); 38±9 yrs). The mRNA levels of enzymes of lipid metabolism (LPL, HSL, and PDE-3B), cortisol production (11βHSD-1), adipogenesis (PPAR-γ1/2), thrombosis and inflammation (PAI-1, IL-6, TNF-α and adiponectin) were determined. AT-LPL mRNA was highest in RL. The highest PDE-3B and lowest PAI-1 mRNA levels were observed in RL and MES. The lowest IL-6 and TNF-α and the highest adiponectin and PPAR-g1/2 mRNA levels were found in RL AT. 11βHSD-1 was highest in RL and OME. A higher lipogenic and adipogenic, and lower pro-inflammatory and pro-thrombotic profiles of the RL suggest a lesser deleterious impact on obesity-related complications.

DOI: 10.1080/21623945.2015.1103404

Cite this paper

@article{Maurige2016GeneEI, title={Gene expression in a rarely studied intraabdominal adipose depot, the round ligament, in severely obese women: A pilot study.}, author={Pascale Mauri{\'e}ge and Denis R. Joanisse and Andr{\'e} Cartier and Isabelle Lemieux and J. Bergeron and Simon Biron and Picard Marceau and Denis Richard}, journal={Adipocyte}, year={2016}, volume={5 1}, pages={27-34} }