Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing.

@article{Siegel2011GeneEI,
  title={Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing.},
  author={Tim Nicolai Siegel and Kapila Gunasekera and George A. M. Cross and Torsten Ochsenreiter},
  journal={Trends in parasitology},
  year={2011},
  volume={27 10},
  pages={434-41}
}
Trypanosoma brucei undergoes major biochemical and morphological changes during its development from the bloodstream form in the mammalian host to the procyclic form in the midgut of its insect host. The underlying regulation of gene expression, however, is poorly understood. More than 60% of the predicted genes remain annotated as hypothetical, and the 5' and 3' untranslated regions important for regulation of gene expression are unknown for >90% of the genes. In this review, we compare the… CONTINUE READING
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Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites

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