Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities.

@article{Shalhoub1991GeneED,
  title={Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities.},
  author={Victoria Shalhoub and Maria E Jackson and Jane B Lian and Gary S Stein and Sandy C. Marks},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 15},
  pages={9847-56}
}
Osteopetrosis is a group of metabolic bone diseases characterized by reductions in osteoclast development and/or function. These aspects of osteoclast biology are known to be influenced by osteoblasts and their products. To ascertain whether osteoblast dysfunction contributes to aberrations in the structural and functional properties of osteoclasts in osteopetrosis, we systematically examined gene expression as reflected by mRNA levels for a series of cell growth- and tissue-related genes… CONTINUE READING