Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck.

@article{Toustrup2012GeneEC,
  title={Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck.},
  author={Kasper Toustrup and Brita Singers S\orensen and Pernille Lassen and Carsten Wiuf and Line Br\ondum and Jens Overgaard},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2012},
  volume={102 1},
  pages={122-9}
}
PURPOSE To validate the predictive impact of a hypoxia gene expression classifier in identifying patients with head and neck squamous cell carcinoma (HNSCC) having benefit from hypoxic modification of radiotherapy. PATIENTS AND METHODS Gene expressions were quantified from formalin-fixed, paraffin-embedded tumour biopsies of 323 HNSCC patients randomized for placebo or nimorazole in conjunction with radiotherapy in the DAHANCA 5 study. Tumours were classified as either "more" or "less… CONTINUE READING

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