Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events.

@article{Emter2013GeneEC,
  title={Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events.},
  author={Roger Emter and J P Wietse van der Veen and Greg Adamson and Janine Ezendam and Henk van Loveren and Andreas Natsch},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2013},
  volume={27 8},
  pages={2225-32}
}
The KeratinoSens™ assay is an in vitro screen for the skin sensitization potential of chemicals. It is based on a luciferase reporter gene under the control of the antioxidant response element of the aldoketoreductase gene AKR1C2. The transferability, reproducibility, and predictivity of the KeratinoSens™ assay have been investigated in detail and it is currently under assessment at the European Center for Validation of Alternatives to animal testing (ECVAM). Here we investigate the sensitizer… CONTINUE READING

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References

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Showing 1-10 of 21 references

Applicability of a keratinocyte

  • J. W. van der Veen, T. E. Pronk, H. van Loveren, J. Ezendam
  • 2013
Highly Influential
4 Excerpts

The intra- and inter-laboratory reproducibility

  • S. Onken, H. Reuter, A. Schepky, R. Emter
  • 2011

oxidase/MAPK/Nrf2 signaling pathway

  • T. Delaine, I. B. Niklasson, R. Emter, K. Luthman, A. T. Karlberg, A. Natsch
  • Free Radic. Biol. Med
  • 2011
2 Excerpts

surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach

  • S.E, I. T. Lee, C. C. Lin, Y. R. Kou, C. M. Yang
  • Regulatory Toxicology and Pharmacology
  • 2010

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