Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray.

@article{Vittal2004GeneEC,
  title={Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray.},
  author={Ragini Vittal and Zachariah E. Selvanayagam and Yi Mike Sun and Jungil Hong and Fang Liu and Khew-Voon Chin and Chung S Yang},
  journal={Molecular cancer therapeutics},
  year={2004},
  volume={3 9},
  pages={1091-9}
}
Many studies suggest green tea is a cancer chemopreventive agent. This effect has been attributed to its major constituent (-)-epigallocatechin-3-gallate (EGCG). EGCG is also observed to have cytotoxic anticancer effects, especially when used in combination with certain chemotherapeutic agents. The biochemical actions of EGCG in chemoprevention and anticancer effects have been studied; however, the mechanisms of action are not clearly understood. We show here by expression genomics the effects… CONTINUE READING