Gene expression changes in human mesenchymal stem cells from patients with osteoporosis

@article{Liu2015GeneEC,
  title={Gene expression changes in human mesenchymal stem cells from patients with osteoporosis},
  author={Lianyong Liu and Qingyun Zhu and Jingnan Wang and Qian Xi and Hongling Zhu and Mingjun Gu},
  journal={Molecular Medicine Reports},
  year={2015},
  volume={12},
  pages={981 - 987}
}
The aim of the present study was to investigate the underlying molecular mechanisms of osteoporosis and to identify novel candidate genes involved in this disease. The gene expression profile of GSE35958 was downloaded from Gene Expression Omnibus, including five samples of human mesenchymal stem cells from patients with osteoporosis and four control samples. Differentially expressed genes (DEGs) were initially identified following an analysis using Student’s t-test. Subsequently, a protein… 

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References

SHOWING 1-10 OF 38 REFERENCES
The Transcriptional Profile of Mesenchymal Stem Cell Populations in Primary Osteoporosis Is Distinct and Shows Overexpression of Osteogenic Inhibitors
TLDR
The results suggest that in primary osteoporosis the transcriptomes of hMSC populations show distinct signatures and little overlap with non-osteoporotic aging, although some hints for senescence-associated changes are detected.
Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system
TLDR
CUMAGAS-OSTEOporosis could be a useful tool for current genomic epidemiology research in the field of osteoporosis and there is evidence of an implication of FA family genes in osteoporeosis.
Genetics of osteoporosis: accelerating pace in gene identification and validation
TLDR
A comprehensive review of developments revealed that, to date, at least 15 genes can be reasonably assigned as confirmed osteoporosis susceptibility genes, whereas, another >30 genes are promising candidate genes.
Regulatory Polymorphisms and Osteoporosis
TLDR
The molecular mechanisms by which common variants at the ERS1, COL1A1 and VDR loci regulate gene expression and predispose to osteoporosis are reviewed.
Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear*
C57BL/6J (B6), but not C3H/HeJ (C3H), mice responded to mechanical loading with an increase in bone formation. A 30-min steady fluid shear of 20 dynes/cm2 increased [3H]thymidine incorporation and
The role of osteopontin: A shared pathway in the pathogenesis of multiple sclerosis and osteoporosis?
Effect of Focal Adhesion Kinase on the Regulation of Realignment and Tenogenic Differentiation of Human Mesenchymal Stem Cells by Mechanical Stretch
TLDR
It is demonstrated that FAK can be activated by mechanical stretch and, with a novel small molecule inhibitor of FAK treatment, FAK autophosphorylation at Tyr397 is significantly decreased, which leads to the attenuation of upregulation of mechanical stretch-induced mRNA expression of tendon-related genes.
TREM2 and β-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis
TLDR
The results reveal that TREM2 regulates the rate of osteoclastogenesis and provide a mechanism for the bone pathology in NHD.
A Rare Haplotype in the Upstream Regulatory Region of COL1A1 Is Associated With Reduced Bone Quality and Hip Fracture
TLDR
This study shows that common genetic variants in the 5′ regulatory region of COL1A1 are associated with biomechanical properties of bone and reduced bone quality by mechanisms independent of their effects on BMD.
...
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