Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation.

@article{Ma2013GeneEC,
  title={Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation.},
  author={Wenxin Ma and Radu Cojocaru and Norimoto Gotoh and Linn Gieser and Rafael Villasmil and Tiziana Cogliati and Anand Swaroop and Wai T Wong},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 10},
  pages={2310-21}
}
Microglia, the resident immune cells of the central nervous system (CNS), are thought to contribute to the pathogenesis of age-related neurodegenerative disorders. It has been hypothesized that microglia undergo age-related changes in gene expression patterns that give rise to pathogenic phenotypes. We compared the gene expression profiles in microglia isolated ex vivo from the retinas of mice ranging from early adulthood to late senescence. We discovered that microglial gene expression… CONTINUE READING

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