Gene expression changes by amyloid β peptide‐stimulated human postmortem brain microglia identify activation of multiple inflammatory processes

  title={Gene expression changes by amyloid $\beta$ peptide‐stimulated human postmortem brain microglia identify activation of multiple inflammatory processes},
  author={Douglas Gordon Walker and John Link and Lih-Fen Lue and Jessica E. Dalsing-Hernandez and Barry Edward Boyes},
  journal={Journal of Leukocyte Biology},
A central feature of the inflammatory pathology in Alzheimer’s disease is activated microglia clustered around aggregated amyloid β (Aβ) peptide‐containing plaques. In vitro‐cultured microglia can be activated to an inflammatory state by aggregated Aβ with the induction of a range of different neurotoxic factors and provide a model system for studying microglia Aβ interactions. Gene expression responses of human postmortem brain‐derived microglia to aggregated Aβ were measured using whole… 

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