Gene expression changes associated with cytotoxicity identified using cDNA arrays


In order to investigate gene expression changes associated with cytotoxicity, we used cDNA arrays to monitor the expression of over 5,000 genes in response to toxic stress in the HepG2 liver cell line. Cells were treated with cytotoxic doses of acetaminophen, caffeine or thioacetamide for nine time points ranging from 1 to 24 h. Samples of mRNA from each… (More)
DOI: 10.1007/s101420000015


13 Figures and Tables