Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex

@article{Tropea2006GeneEC,
  title={Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex},
  author={Daniela Tropea and Gabriel Kreiman and Alvin W Lyckman and Sayan Mukherjee and Hongbo Yu and Sam Horng and Mriganka Sur},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={660-668}
}
Two key models for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD). Combining DNA microarray analysis with computational approaches, RT-PCR, immunohistochemistry and physiological imaging, we find that DR leads to (i) upregulation of genes subserving synaptic transmission and electrical activity, consistent with a coordinated… CONTINUE READING
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