Gene expression cascades in pancreatic development

  title={Gene expression cascades in pancreatic development},
  author={Maria E. Wilson and David W. Scheel and Michael S. German},
  journal={Mechanisms of Development},
The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of apparently identical cells in the early gut endoderm. Serial changes in their gene expression program, controlled by a hierarchy of pancreatic transcription factors, direct this progression from multipotent progenitor cell to mature pancreatic cell. When the cells differentiate, this hierarchy of factors coalesces into a network of factors that maintain the differentiated phenotype of the cells. As we… CONTINUE READING
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