Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery.

@article{Woelk2010GeneEB,
  title={Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery.},
  author={Christopher H. Woelk and Nadejda S Beliakova-Bethell and Miguel Goicoechea and Yingdong Zhao and Pinyi Du and Steffney E. Rought and Jean Lozach and Josu{\'e} P{\'e}rez-Santiago and Douglas D. Richman and Davey M. Smith and Susan J. Little},
  journal={AIDS},
  year={2010},
  volume={24 2},
  pages={
          217-22
        }
}
OBJECTIVE To identify a pre-HAART gene expression signature in peripheral blood mononuclear cells (PBMCs) predictive of CD4 T-cell recovery during HAART in HIV-infected individuals. DESIGN This retrospective study evaluated PBMC gene expression in 24 recently HIV-infected individuals before the initiation of HAART to identify genes whose expression is predictive of CD4 T-cell recovery after 48 weeks of HAART. METHODS The change in CD4 T-cell count (DeltaCD4) over the 48-week study period… CONTINUE READING

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