Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery.

@article{Rosell2004GeneEA,
  title={Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery.},
  author={Rafael Rosell and E Felip and M{\`i}quel Taron and J. P. Majo and Pedro E M{\'e}ndez and Mar{\'i}a S{\'a}nchez-Ronco and Cristina Queralt and Jos{\'e} Javier S{\'a}nchez and Jose Maestre},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 12 Pt 2},
  pages={4215s-4219s}
}
PURPOSE The first suggestions of a relationship between gene mRNA expression and differential sensitivity to gemcitabine/cisplatin are now emerging. ERCC1, RRM1, and XPD are involved in the nucleotide excision repair pathways, and tumor up-regulation of these genes leads to chemotherapy failure. In the present study, we have examined the potential correlation and predictive value of ERCC1, RRM1, and XPD mRNA expression in resected specimens from 67 stage IIB, IIIA, and IIIB non-small cell lung… CONTINUE READING
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