Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

@article{Sikalidis2010GeneEA,
  title={Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium},
  author={Angelos K. Sikalidis and Jeong-In Lee and Martha H. Stipanuk},
  journal={Amino Acids},
  year={2010},
  volume={41},
  pages={159-171}
}
The integrated stress response (ISR), a defense mechanism cells employ when under stress (e.g., amino acid deprivation), causes suppression of global protein synthesis along with the paradoxical increased expression of a host of proteins that are useful in combating various stresses. Genes that were similarly differentially expressed under conditions of either leucine- or cysteine-depletion were identified. Many of the genes known to contain an amino acid response element and to be induced in… CONTINUE READING