Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices.

@article{Brophy2010GeneEA,
  title={Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices.},
  author={Colleen Marie Brophy and Jennifer L Luebke-Wheeler and Bruce P. Amiot and Rory P. Remmel and Piero Rinaldo and Scott L. Nyberg},
  journal={Cells, tissues, organs},
  year={2010},
  volume={191 2},
  pages={129-40}
}
Long term culture of primary hepatocytes is valuable for diagnostic and therapeutic applications. However, standard monolayer culture of primary hepatocytes on tissue culture plastic (TCP) - either uncoated or coated with a biological material such as collagen or laminin - is problematic. Thus, novel support matrices are under development to better maintain gene expression and differentiated function of primary hepatocytes in vitro. In this study, a fabricated nanofiber matrix was compared to… CONTINUE READING
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Reproduced with the permission

  • AG S.Karger, Basel
  • 2010

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