Gene expression and epigenetic changes by furan in rat liver.

  title={Gene expression and epigenetic changes by furan in rat liver.},
  author={Tao Chen and Tim D. Williams and Angela Mally and Carolin Hamberger and Leda Mirbahai and Kevin Hickling and James Kevin Chipman},
  volume={292 2-3},
Furan, a widely used industrial compound, has been found in a number of heated food items. Furan is carcinogenic to rats and mice, but the mechanism behind its carcinogenic effect is still not well understood. In this study, we tested the hypothesis that alteration of gene expression relating to cell cycle, apoptosis, DNA damage and of epigenetic modifications including miRNA and DNA methylation may contribute to rodent carcinogenicity of furan. Using quantitative PCR arrays specific to cell… CONTINUE READING

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Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2016
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