Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer

@article{Wikman2007GeneEA,
  title={Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer},
  author={Harriet Wikman and Salla Ruosaari and Penny Nymark and Virinder Kaur Sarhadi and Juha Saharinen and Esa Vanhala and Antti Karjalainen and Jaakko Hollm{\'e}n and Sakari Knuutila and Sisko Anttila},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={4730-4737}
}
Asbestos is a pulmonary carcinogen known to give rise to DNA and chromosomal damage, but the exact carcinogenic mechanisms are still largely unknown. In this study, gene expression arrays were performed on lung tumor samples from 14 heavily asbestos-exposed and 14 non-exposed patients matched for other characteristics. Using a two-step statistical analysis, 47 genes were revealed that could differentiate the tumors of asbestos-exposed from those of non-exposed patients. To identify asbestos… CONTINUE READING

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