Gene expression analysis reveals evidence for inactivation of the TGF-β signaling cascade in autonomously functioning thyroid nodules

@article{Eszlinger2004GeneEA,
  title={Gene expression analysis reveals evidence for inactivation of the TGF-β signaling cascade in autonomously functioning thyroid nodules},
  author={M. Eszlinger and Knut Krohn and Romy Frenzel and Siegfried Kropf and Anke Toenjes and R. Paschke},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={795-804}
}
Molecular eventsthat lead to the development of autonomously functioning thyroid nodules (AFTNs) are somatic mutations of the thyrotropin receptor (TSHR) in approximately 60% of the nodules and less frequently, somatic mutations in the Gsα protein. However, AFTNs without known mutations indicate that other causes remain to be identified. Moreover, the impact of constitutively activating TSHR mutations on the signal transduction network of the thyroid epithelial cell is unknown. We therefore… CONTINUE READING