Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells.

@article{Gardiner2013GeneEA,
  title={Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells.},
  author={Erin J Gardiner and Murray J. Cairns and Bing Liu and Natalie Jane Beveridge and Vaughan J. Carr and Brian Kelly and Rodney J. Scott and Paul A. Tooney},
  journal={Journal of psychiatric research},
  year={2013},
  volume={47 4},
  pages={425-37}
}
Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide insight into the molecular basis of the disorder. This study used the Illumina HT_12 microarray platform and quantitative real time PCR (QPCR) to perform mRNA expression profiling on 114 patients with schizophrenia or schizoaffective disorder and 80 non-psychiatric controls from the Australian Schizophrenia Research Bank (ASRB). Differential… CONTINUE READING