Gene expression analysis of plasmablastic lymphoma identifies downregulation of B-cell receptor signaling and additional unique transcriptional programs

Plasmablastic lymphoma (PBL) is a distinct aggressive B-cell malignancy characterized by a terminally differentiated B-cell phenotype. It usually occurs in immunocompromised patients, either in the setting of HIV infection or in patients with iatrogenic immunosuppression and advanced age. Histopathologic features of PBL include immunoblastic and/or… CONTINUE READING