Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance.

@article{Holzbeierlein2004GeneEA,
  title={Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance.},
  author={Jeff Holzbeierlein and Priti Lal and Eva Latulippe and Alex Smith and Jaya M. Satagopan and Liying Zhang and Charles T. Ryan and Steve Smith and Howard I. Scher and Peter T. Scardino and Victor E. Reuter and William L. Gerald},
  journal={The American journal of pathology},
  year={2004},
  volume={164 1},
  pages={217-27}
}
The androgen-signaling pathway is critical to the development and progression of prostate cancer and androgen ablation is a mainstay of therapy for this disease. We performed a genome-wide expression analysis of human prostate cancer during androgen ablation therapy to identify genes regulated by androgen and genes differentially expressed after the development of resistance. Six hundred and fifty-four of 63,175 probe sets detected significant expression changes after 3 months of treatment with… CONTINUE READING
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