Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets.

@article{Cameron2008GeneEA,
  title={Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets.},
  author={Cheryl M. Cameron and Mark J Cameron and Jesus F Bermejo-Martin and Longsi Ran and Luoling Xu and Patricia V Turner and Ran Ran and Ali Karimi Danesh and Yuan Fang and Pak-Kei Chan and Nutan Mytle and Timothy John Sullivan and Tassie L Collins and Michael Gilbert Johnson and Julio C{\'e}sar Cort{\'e}s Medina and Thomas E. Rowe and David Joseph Kelvin},
  journal={Journal of virology},
  year={2008},
  volume={82 22},
  pages={
          11308-17
        }
}
How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of avian influenza virus infection in humans is poorly understood. We identified three clusters of differentially expressed innate immune response genes in lungs from H5N1 (A/Vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis. Interferon response genes were more strongly expressed in H5N1-infected ferret lungs than in lungs from ferrets infected with the less pathogenic… CONTINUE READING
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