Gene expression analysis identifies global gene dosage sensitivity in cancer

  title={Gene expression analysis identifies global gene dosage sensitivity in cancer},
  author={Rudolf S. N. Fehrmann and Juha M Karjalainen and Małgorzata Krajewska and Harm-Jan Westra and David J. Maloney and Anton Simeonov and Tune H. Pers and Joel Hirschhorn and Ritsert C. Jansen and Erik Schultes and Herman H. H. B. M. van Haagen and Elisabeth G. E. de Vries and Gerard J. te Meerman and Cisca Wijmenga and Marcel A T M van Vugt and Lude Franke},
  journal={Nature Genetics},
Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently, one of the challenges is to identify the molecular downstream effects of these variants. Although several SCNAs are known to change gene expression levels, it is not clear whether each individual SCNA affects gene expression. We reanalyzed 77,840 expression profiles and observed a limited set of 'transcriptional components' that describe well-known biology, explain the vast majority of variation in gene… CONTINUE READING
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