Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals.

@article{Patterson2006GeneEA,
  title={Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals.},
  author={Rachel M. Patterson and Dori R. Germolec},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1076},
  pages={718-27}
}
Exposure to environmental agents can affect a number of adverse immunological outcomes, including changes in the incidence of infectious disease. Diethylstilbestrol (DES), dexamethasone (DEX), cyclophosphamide, and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are immunosuppressive chemicals that can induce similar pathophysiological end points in the thymus; however, the mechanism of toxicity is different for each compound. We examined differential gene expression in the spleen and thymus… CONTINUE READING