Gene expression: chromatin and transcription factors: who's on first?

  • K. Struhl
  • Published 1993 in Current biology : CB

Abstract

Chromatin is the physiologically relevant template for transcription: chromatin structure and transcriptional ini tiation must therefore be mechanistically linked. Nuccleosome coating of the DNA severely restricts the access of transcription factors to promoters. Nucleosomal templates are transcribed much less efficiently than naked DNA templates in vitro… (More)

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