Gene expression: UV-induced coupling

Abstract

to be a key response to DNA damage because many apoptotic genes are alternatively spliced, but the under­ lying mechanism is unknown. A new study by Kornblihtt and colleagues reports that ultraviolet (UV) irradia­ tion triggers co­transcriptional AS, through the hyperphosphorylation of the carboxy­terminal domain (CTD) on RNA polymerase II and through the… (More)
DOI: 10.1038/nrm2715

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