Gene essentiality and the topology of protein interaction networks.

Abstract

The mechanistic bases for gene essentiality and for cell mutational resistance have long been disputed. The recent availability of large protein interaction databases has fuelled the analysis of protein interaction networks and several authors have proposed that gene dispensability could be strongly related to some topological parameters of these networks… (More)

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@article{Coulomb2005GeneEA, title={Gene essentiality and the topology of protein interaction networks.}, author={St{\'e}phane Coulomb and Michel Bauer and Denis Bernard and Marie-Claude Marsolier-Kergoat}, journal={Proceedings. Biological sciences}, year={2005}, volume={272 1573}, pages={1721-5} }