Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges.

@article{Cornelis2012GeneenvironmentII,
  title={Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges.},
  author={Marilyn C Cornelis and Frank B Hu},
  journal={Annual review of nutrition},
  year={2012},
  volume={32},
  pages={
          245-59
        }
}
Type 2 diabetes (T2D) is thought to arise from the complex interplay of both genetic and environmental factors. Since the advent of genome-wide association studies (GWAS), we have seen considerable progress in our understanding of the role that genetics and gene-environment interactions play in the development of T2D. Recent work suggests that the adverse effect of several T2D loci may be abolished or at least attenuated by higher physical activity levels or healthy lifestyle, whereas low… CONTINUE READING

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