Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study.

Abstract

OBJECTIVES To investigate associations of Parkinson's disease (PD) and parkinsonian syndromes with polymorphic genes that influence metabolism of either foreign chemical substances or dopamine and to seek evidence of gene-environment interaction effects that modify risk. METHODS A case-control study of 959 prevalent cases of parkinsonism (767 with PD) and… (More)

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