Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness

@article{Pinto2007GeneenvironmentII,
  title={Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness},
  author={Lawrence H. Pinto and Emily Eaton and Bohao Chen and Jonah Fleisher and Dmitry Shuster and Joel McCauley and Dalius Kedainis and Sandra M. Siepka and Kazuhiro Shimomura and Eun-joo Song and Aliya Husain and Oren J. Lakser and Richard W. Mitchell and Maria L. Dowell and Melanie Brown and Blanca Camoretti-Mercado and Robert N. Naclerio and Anne I. Sperling and Stephen I. Levin and Fred W Turek and Julian Solway},
  journal={Mammalian Genome},
  year={2007},
  volume={19},
  pages={2-14}
}
We mutagenized male BTBR mice with N-ethyl-N-nitrosourea and screened 1315 of their G3 offspring for airway hyperresponsiveness. A phenovariant G3 mouse with exaggerated methacholine bronchoconstrictor response was identified and his progeny bred in a nonspecific-pathogen-free (SPF) facility where sentinels tested positive for minute virus of mice and mouse parvovirus and where softwood bedding was used. The mutant phenotype was inherited through G11 as a single autosomal semidominant mutation… CONTINUE READING