Gene-environment interactions: lifetime cognitive activity, APOE genotype, and β-amyloid burden.

@article{Wirth2014GeneenvironmentIL,
  title={Gene-environment interactions: lifetime cognitive activity, APOE genotype, and β-amyloid burden.},
  author={Miranka Wirth and Sylvia Villeneuve and Renaud La Joie and Shawn M Marks and William J. Jagust},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 25},
  pages={8612-7}
}
Carriers of the apolipoprotein E (APOE) ε4 allele, the major genetic risk for Alzheimer's disease (AD), harbor an increased load of β-amyloid (Aβ) plaque burden that is felt to be a major instigator of AD development. Data has suggested that lifestyle factors may reduce AD risk by directly mitigating Aβ pathology, which could be particularly beneficial in APOE ε4 carriers. We therefore examined the interaction between lifetime cognitive activity and the APOE ε4 allele in relation to brain A… CONTINUE READING

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