Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.

@article{Melkonian2016GeneenvironmentIO,
  title={Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.},
  author={Stephanie C Melkonian and Carrie R Daniel and Yuanqing Ye and Nizar M. Tannir and Jose A Karam and Surena F Matin and Christopher G Wood and Xifeng Wu},
  journal={Cancer},
  year={2016},
  volume={122 1},
  pages={108-15}
}
BACKGROUND Meat-cooking mutagens may be associated with renal cell carcinoma (RCC) risk. In the current study, the authors examined associations between meat-cooking mutagens, genetic susceptibility variants, and risk of RCC. METHODS The authors used 659 newly diagnosed RCC cases and 699 healthy controls to investigate the association between dietary intake of meat-cooking mutagens and RCC. They examined whether associations varied by risk factors for RCC and genetic susceptibility variants… CONTINUE READING
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