Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol.


Alzheimer's disease is probably a complex disease caused by an interaction of multiple environmental and genetic factors. Genetic defects include 'causative' genes which are rare and a 'susceptibility' gene (sigma4 allele of apolipoprotein E) which is more common in cases. Recent research suggests that environmental factors may interact with a genetic predisposition to modify the risk of Alzheimer's disease. An interaction between serum cholesterol levels and sigma4 genotype is proposed. The evidence for this gene-environment interaction is discussed.


Citations per Year

108 Citations

Semantic Scholar estimates that this publication has 108 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Chandra1998GeneenvironmentII, title={Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol.}, author={Vipan Chandra and Rijuta Pandav}, journal={Neuroepidemiology}, year={1998}, volume={17 5}, pages={225-32} }