Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites§

@article{Hunt2007GeneEA,
  title={Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites§},
  author={Paul N. Hunt and Ana Barahona Afonso and Alison M. Creasey and Richard Culleton and Amar Bir Sidhu and John Logan and Stephanie Gaw Valderramos and Iain W. McNae and Sandra Cheesman and Virg{\'i}lio Est{\'o}lio do Ros{\'a}rio and Richard Carter and David A. Fidock and Pedro Manuel Mendonça Silva Cravo},
  journal={Molecular Microbiology},
  year={2007},
  volume={65},
  pages={27 - 40}
}
Artemisinin- and artesunate-resistant Plasmodium chabaudi mutants, AS-ART and AS-ATN, were previously selected from chloroquine-resistant clones AS-30CQ and AS-15CQ respectively. Now, a genetic cross between AS-ART and the artemisinin-sensitive clone AJ has been analysed by Linkage Group Selection. A genetic linkage group on chromosome 2 was selected under artemisinin treatment. Within this locus, we identified two different mutations in a gene encoding a deubiquitinating enzyme. A distinct… CONTINUE READING