Gene-editing nucleases

  title={Gene-editing nucleases},
  author={M. Baker},
  journal={Nature Methods},
  • M. Baker
  • Published 2011
  • Biology, Medicine
  • Nature Methods
ways to modify sequences in the genome, a powerful technique. Even as the genome sequences of many organisms are being revealed, understanding what those genes really do requires tweaking the sequences, deleting or modifying genes, and studying the consequences. With the exceptions of those from mice and yeast, however, eukaryotic genomes generally resist this type of precise tinkering. Engineered gene-editing nucleases are now poised to change that. Over the past 15 years, researchers have… Expand
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