Gene editing: not just for translation anymore.


Moira A. McMahon, Meghdad Rahdar and Matthew Porteus are at Stanford University, Stanford, California, USA. e-mail: the most striking results so far have been obtained with ZFNs, genome editing is possible with all three nuclease types. It is possible that TALENs will supplant ZFNs as the genome-editing tool of choice, because they are easier than ZFNs to assemble and have near-equal activity. But ZFNs and modified homing endonucleases will probably continue to have an important role as well.

DOI: 10.1038/nmeth.1811

A m er ic a, In c. A ll ri g h ts r es

  • F Soldner
  • 2011
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