Gene editing at CRISPR speed

@article{Baker2014GeneEA,
  title={Gene editing at CRISPR speed},
  author={Monya Baker},
  journal={Nature Biotechnology},
  year={2014},
  volume={32},
  pages={309-312}
}
The inner workings CRISPR-Cas creates double-stranded cuts in DNA, triggering DNA repair mechanisms that can knock out a gene by breaking its sequence or, more rarely, tweak a gene by inserting an alternative DNA sequence from another template. It is not the only gene-editing technology that works this way. ZFNs, described first in 1996 (ref. 11) combine the DNA-cutting domain of a bacterial restriction enzyme with DNA-recognition elements; TALENs, reported in 2009, are also fusions (the same… CONTINUE READING
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