Gene editing: not just for translation anymore

@article{McMahon2011GeneEN,
  title={Gene editing: not just for translation anymore},
  author={Moira A. McMahon and M. Rahdar and M. Porteus},
  journal={Nature Methods},
  year={2011},
  volume={9},
  pages={28-31}
}
Engineered nucleases have advanced the field of gene therapy with the promise of targeted genome modification as a treatment for human diseases. Here we discuss why engineered nucleases are an exciting research tool for gene editing and consider their applications to a range of biological questions. 
59 Citations
Quantifying on- and off-target genome editing.
  • 109
Key to Delivery: The (Epi-)genome Editing Vector Toolbox.
Improvements in Gene Editing Technology Boost Its Applications in Livestock
Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders
  • 11
  • PDF
Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing.
  • 105
Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells.
  • 24
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
A TALE nuclease architecture for efficient genome editing
  • 1,628
  • PDF
Genome editing with engineered zinc finger nucleases
  • 1,648
  • PDF
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
  • 1,423
  • PDF
Genetic engineering of human ES and iPS cells using TALE nucleases
  • 428
  • PDF
Genetic manipulation of genomes with rare-cutting endonucleases.
  • M. Jasin
  • Biology, Medicine
  • Trends in genetics : TIG
  • 1996
  • 371
Generation of a triple‐gene knockout mammalian cell line using engineered zinc‐finger nucleases
  • 109
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
  • 345
  • PDF
...
1
2
3
...