Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age

@inproceedings{Fokkens2012GeneDC,
  title={Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age},
  author={Like Fokkens and Paulien Hogeweg and Berend Snel},
  booktitle={BMC Evolutionary Biology},
  year={2012}
}
BackgroundThe study of biological networks and how they have evolved is fundamental to our understanding of the cell. By investigating how proteins of different ages are connected in the protein interaction network, one can infer how that network has expanded in evolution, without the need for explicit reconstruction of ancestral networks. Studies that implement this approach show that proteins are often connected to proteins of a similar age, suggesting a simultaneous emergence of interacting… CONTINUE READING
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