Gene duplication and inactivation in the HPRT gene family.

@article{Keebaugh2007GeneDA,
  title={Gene duplication and inactivation in the HPRT gene family.},
  author={Alaine C. Keebaugh and Robert T. Sullivan and James W. Thomas},
  journal={Genomics},
  year={2007},
  volume={89 1},
  pages={
          134-42
        }
}
Hypoxanthine phosphoribosyltransferase (HPRT1) is a key enzyme in the purine salvage pathway, and mutations in HPRT1 cause Lesch-Nyhan disease. The studies described here utilized targeted comparative mapping and sequencing, in conjunction with database searches, to assemble a collection of 53 HPRT1 homologs from 28 vertebrates. Phylogenetic analysis of these homologs revealed that the HPRT gene family expanded as the result of ancient vertebrate-specific duplications and is composed of three… CONTINUE READING

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