Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

@article{Corder1993GeneDO,
  title={Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.},
  author={Elizabeth H. Corder and Ann M Saunders and Warren J. Strittmatter and Donald E. Schmechel and Perry C. Gaskell and Gary W. Small and A. D. Roses and Jonathan L. Haines and Margaret A. Pericak-Vance},
  journal={Science},
  year={1993},
  volume={261 5123},
  pages={921-3}
}
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD… CONTINUE READING
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