Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

@article{Corder1993GeneDO,
  title={Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.},
  author={Elizabeth H. Corder and Ann M Saunders and Warren J. Strittmatter and Detlef Schmechel and Peter C. Gaskell and Gary W. Small and Allen D. Roses and Jonathan L. Haines and Margaret A. Pericak-Vance},
  journal={Science},
  year={1993},
  volume={261 5123},
  pages={
          921-3
        }
}
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD… Expand
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease
TLDR
This work assessed whether the APOE genotype had an influence on the age of onset of AD in chromosome 14 linked early-onset AD families and no significant effect of the APoe genotype on onset age could be detected. Expand
Allele doses of apolipoprotein E type epsilon 4 in sporadic late-onset Alzheimer's disease.
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It is found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-epsilon 4 in sporadic, late-onset French AD. Expand
Apolipoprotein E genotypes and age of onset in early‐onset familial Alzheimer's disease
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Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease.
TLDR
Data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD. Expand
ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease
TLDR
Analysis of the ApoE gene polymorphism in a sample of 446 Italian subjects confirmed a significant association between epsilon 4 allele and sporadic Alzheimer's disease (AD) and found a not previously reported association between apolipoprotein E (ApoE) Epsilon 2 alleles and sporadic AD and EOFAD. Expand
Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers.
TLDR
Highly significant enrichment is found for both homozygote and heterozygote ApoE epsilon 4 allele carriers in familial and sporadic early onset AD with a pattern closely resembling that in late onset AD. Expand
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
TLDR
A protective effect of the ε2 allele, in addition to the dose effect ofThe ε4 allele in sporadic AD, is demonstrated, which further support the direct involvement of APOE in the pathogenesis of AD. Expand
ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val → Ile mutated families
TLDR
In none of the FAD families analysed was there a significant effect of the ApoE genotype on the age of onset with the exception of one of the two mutated EOFAD families in which the epsilon 2 allele delayed theAge of onset. Expand
Apolipoprotein E alleles as risk factors in Alzheimer's disease.
  • A. Roses
  • Biology, Medicine
  • Annual review of medicine
  • 1996
TLDR
A major susceptibility locus, apolipoprotein E (APOE, gene; apoE, protein) is associated with risk and age of onset distributions for the common familial and sporadic late-onset AD. Expand
Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus
TLDR
It is confirmed that familial clustering in late onset Alzheimer's disease is associated with the zeta 4 allele of apolipoprotein E, and it is suggested that the effect of a single zeta4 allele is to increase the risk of developing AD by an amount equivalent to 5 years. Expand
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