Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts.

@article{Warot1997GeneDE,
  title={Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts.},
  author={Xavier M Warot and Catherine Fromental-Ramain and Val{\'e}rie Fraulob and Pierre Chambon and Pascal Doll{\'e}},
  journal={Development},
  year={1997},
  volume={124 23},
  pages={
          4781-91
        }
}
Gene targeting experiments have shown that the murine Hoxa-13 and Hoxd-13 paralogous genes control skeletal patterning in the distal region of the developing limbs. However, both genes are also expressed in the terminal part of the digestive and urogenital tracts during embryogenesis and postnatal development. Here, we report the abnormalities occuring in these systems in Hoxa-13(-/-) and Hoxa-13/Hoxd-13 compound mutant mice. Hoxa-13(-/-) mutant fetuses show agenesis of the caudal portion of… CONTINUE READING

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