Gene dosage and complementation analysis of the Shaker locus in Drosophila.

@article{Timpe1987GeneDA,
  title={Gene dosage and complementation analysis of the Shaker locus in Drosophila.},
  author={Leslie C Timpe and Lily Yeh Jan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1987},
  volume={7 5},
  pages={1307-17}
}
Mutations of the Shaker (Sh) locus alter or eliminate a transient, voltage-sensitive potassium current, the "A" current, in flight muscle of Drosophila. We show that the amplitude of the A current is reduced when the dosage of Sh+ is lower than normal, but that A current amplitude does not increase as extra copies of Sh+ are added. We have also examined 14 Shaker mutants by voltage clamp and by intracellular recording at the larval neuromuscular junction. In 10 of these mutants there is no… CONTINUE READING