Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma

@article{Kersting2004GeneDP,
  title={Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma},
  author={Christian M. Kersting and Nicola Tidow and Hartmut Schmidt and Cornelia Liedtke and Joerg L Neumann and Werner Boecker and Paul J. van Diest and Burkhard Brandt and Horst Buerger},
  journal={Laboratory Investigation},
  year={2004},
  volume={84},
  pages={582-587}
}
The aim of this study was to assess the frequency of egfr whole gene and CA intron repeat amplification in invasive breast cancer as a mechanism for epidermal growth factor receptor (EGFR) protein overexpression. By means of tissue microarrays, protein overexpression and whole gene amplification were assessed in 222 cases of invasive breast cancer by immunohistochemistry and FISH, respectively. First intron CA repeat amplification was assessed by Taqman RT-PCR. With FISH and RT-PCR, 4.7 and 6.3… CONTINUE READING

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