Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum.

@article{Sijwali2006GeneDD,
  title={Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum.},
  author={Puran Singh Sijwali and Jamie Koo and Naresh Singh and Philip J. Rosenthal},
  journal={Molecular and biochemical parasitology},
  year={2006},
  volume={150 1},
  pages={96-106}
}
Erythrocytic stages of the malaria parasite Plasmodium falciparum express four related papain-family cysteine proteases, termed falcipains. Falcipain-2 and falcipain-3 are food vacuole hemoglobinases, but determination of the specific roles of these and other falcipains has been incomplete. To better characterize biological roles, we attempted disruption of each falcipain gene in the same strain (3D7) of P. falciparum. Disruption of falcipain-1, falcipain-2, and falcipain-2' was achieved. In… CONTINUE READING
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