Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.

@article{Lwenheim1999GeneDO,
  title={Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.},
  author={H. L{\"o}wenheim and D. Furness and J. Kil and C. Zinn and K. G{\"u}ltig and M. Fero and D. Frost and A. Gummer and J. Roberts and E. Rubel and C. Hackney and H. Zenner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 7},
  pages={
          4084-8
        }
}
Hearing loss is most often the result of hair-cell degeneration due to genetic abnormalities or ototoxic and traumatic insults. In the postembryonic and adult mammalian auditory sensory epithelium, the organ of Corti, no hair-cell regeneration has ever been observed. However, nonmammalian hair-cell epithelia are capable of regenerating sensory hair cells as a consequence of nonsensory supporting-cell proliferation. The supporting cells of the organ of Corti are highly specialized, terminally… Expand
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TLDR
Findings indicate that p27(Kip1) acts to regulate the growth of a variety of cells, and surprises us by keeping the cell cycle arrest mediated by TGFbeta, rapamycin, or contact inhibition intact in p27(-/-) cells. Expand
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These observations are the first to identify a signaling pathway that plays a role in regenerative proliferation in the auditory receptor epithelium that is blocked by inhibitors of the cAMP–regulated protein kinase A (PKA). Expand
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None of the labeled cells in their study could be identified as hair cells, which indicates that proliferation might not be the only process involved in the appearance of immature hair cells in the drug-damaged mammalian urtricles. Expand
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The results have demonstrated that hair cells that have similar stereocilia phenotypes do not all leave the mitotic cycle at the same time. Expand
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The expression pattern of mouse p21 correlated with terminal differentiation of multiple cell lineages including skeletal muscle, cartilage, skin, and nasal epithelium in a p53-independent manner, demonstrating that p21 expression does not require these transcription factors. Expand
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TLDR
P27 deficiency may cause a cell-autonomous defect resulting in enhanced proliferation in response to mitogens, and in the spleen, the absence of p27 selectively enhanced proliferation of hematopoietic progenitor cells. Expand
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TLDR
The discovery that hundreds of thousands of hair cells are added to the ears of postembryonic sharks progressively in size and shape along and across the led to the proposal that hair-cell loss might be repaired epithelium, as do the numbers, dimensions, and geovia regenerative replacement mechanisms. Expand
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It is suggested that the supporting cells play a protective and trophic role in the recovery of injured hair cells following laser beam irradiation of Corti. Expand
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