Gene discovery using the serial analysis of gene expression technique: implications for cancer research.

@article{Polyk2001GeneDU,
  title={Gene discovery using the serial analysis of gene expression technique: implications for cancer research.},
  author={Korn{\'e}lia Poly{\'a}k and Gregory Joseph Riggins},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2001},
  volume={19 11},
  pages={2948-58}
}
Cancer is a genetic disease. As such, our understanding of the pathobiology of tumors derives from analyses of the genes whose mutations are responsible for those tumors. The cancer phenotype, however, likely reflects the changes in the expression patterns of hundreds or even thousands of genes that occur as a consequence of the primary mutation of an oncogene or a tumor suppressor gene. Recently developed functional genomic approaches, such as DNA microarrays and serial analysis of gene… CONTINUE READING